Both ties are still tight after the first legs of the 2018 African Nations Championship first round Southern Zone qualifiers played at the weekend.
Madagascar edged to a 1-0 home victory over COSAFA rivals Malawi, but now face a daunting trip away to Blantyre to finish the job this coming weekend.
Morelin Raveloarisona scored the only goal of the game with four minutes remaining on the clock.
Mauritius gained a 2-1 home win over fellow islanders Seychelles, but will know there is plenty more work to be done in the return.
Emmanuel Vincent Jean and Francis Rasolofonirina had Mauritius 2-0 up, but Manoo Yannick Dominique netted 12 minutes from time for what could still b e a crucial away goal for the Seychelles.
The winners of the two ties will advance to the next round of qualifying in July.
Mozambique away the winner of Madagascar/Malawi, while Angola will take on the victor between Mauritius and Seychelles.